Devazepide (L-364,718, MK-329) is benzodiazepine drug, but with quite different actions from most benzodiazepines, lacking affinity for GABAA receptors and instead acting as an CCKA receptor antagonist. It increases appetite and accelerates gastric emptying, and has been suggested as a potential treatment for a variety of gastrointestinal problems including dyspepsia, gastroparesis and gastric reflux. It is also widely used in scientific research into the CCKA receptor.

Synthesis

Devazepide is synthesised in a similar manner to other benzodiazepines.

See also

  • Benzodiazepine
  • Cholecystokinin antagonist

References


Die Rolle von Benzodiazepinen und Dexmedetomidin bei der Behandlung von

Diazepam N05BA01

CategoryDevazepide Wikimedia Commons

Benzodiazepine Paradebeispiel für zweischneidiges Schwert

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